Kratom, derived from the Mitragyna speciosa plant, contains alkaloids such as mitragynine and 7-hydroxymitragynine that have gained popularity in nutraceutical research. For laboratories seeking high-purity extracts with reproducible results, utilizing a CO2 supercritical extraction machine optimized for kratom offers a precise, safe, and solvent-free method.
Traditional ethanol or hydrocarbon extractions carry risks of residual solvents and inconsistent profiles. Labs now prefer CO2 supercritical extraction machines because they:
Avoid chemical solvents entirely
Offer programmable precision for temperature and pressure
Enable cleaner extraction of alkaloids and terpenes
Support GMP and ISO-compliant laboratory workflows
This makes CO2 ideal for labs developing kratom-based formulations intended for clinical studies or dietary supplements.
Kratom leaves require tailored parameters to effectively extract active alkaloids:
Pressure: Operating between 2,000–3,000 psi optimizes mitragynine yield
Temperature: Maintaining 38–45°C protects alkaloid structure
Flow rate: Fine-tuned CO2 flow maximizes mass transfer and selectivity
A CO2 supercritical extraction machine with programmable logic controls and inline data logging enables labs to adjust these variables in real time and capture repeatable results.
To meet scientific standards, lab-specific CO2 extractors include:
Compact footprint for benchtop use
Removable stainless-steel vessels
Real-time extraction monitoring
Modular design for upgrading or customization
These systems are designed to be both efficient and adaptable, enabling labs to quickly iterate extraction methods and optimize alkaloid purity.
Batch consistency for clinical-grade formulations
Improved bioavailability of final kratom extracts
Full traceability of extraction variables
No solvent residues, eliminating further purification steps