Pharmaceutical-Grade CO2 Extraction: A Supercritical Approach

Introduction

Pharmaceutical-grade botanical and cannabis extracts require high purity, solvent-free processing, and precise compound isolation to meet GMP (Good Manufacturing Practice) and regulatory standards. The extraction method is crucial in ensuring bioavailability, consistency, and therapeutic efficacy.

Traditional methods, such as solvent-based extraction (ethanol, hexane) and steam distillation, often result in residual solvents, inconsistent compound profiles, and degradation of sensitive bioactives.

CO2 supercritical extraction (CO2 SUPERCRITICAL EXTRACTION MACHINE) is the gold standard for producing pharmaceutical-grade extracts, offering high precision, clean processing, and eco-friendly solvent-free extraction.

This article explores the CO2 extraction process for pharmaceutical-grade products, key parameters, experimental data, and industrial applications.

1. Principles of CO2 Supercritical Extraction for Pharmaceuticals

CO2 becomes a supercritical fluid at 31.1°C and 7.38 MPa, allowing it to penetrate botanical material and selectively dissolve bioactive compounds while leaving behind undesirable plant materials like chlorophyll and waxes.

The CO2 supercritical extraction process for pharmaceuticals consists of:...

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